Correlation between necrotizing enterocolitis in preterm infants and cytomegalovirus infection

HUANG Yong

doi:10.3969/j.issn.1002-7386.2018.09.004

Abstract：Objective To investigate the correlation between pathogenesis,progression and prognosis of necrotizing enterocolitis (NEC) in preterm infants and human cytomegaloviru(HCMV)infection. Methods A total of 103 premature infants with NEC were divided into three groups;NEC stageⅠgroup(n=35),NEC stageⅡgroup(n=38) and NEC stageⅢ group (n=30),at the same time,the other 30 healthy preterm infants were served as control group.HCMV PP65 antigen and HCMV-IgG,HCMV-IgM antibody were detected.Moreover these premature infants with NEC were redivided into death group and survival group according to the prognosis of patients.Results The positive rates of HCMV-PP65,HCMV-IgM and HCMV-IgM/IgG in NEC stage Ⅲ group were the highest among the four groups,and which were the lowest in control group (P<0.05).However the negative rate of HCMV-IgM/IgG and the positive rate of HCMV-IgG were the highest in control group,which were the lowest in NEC stageⅢgroup(P<0.05). The positive rates of HCMV-PP65 and HCMV-IgM/IgG had an increase tendency in control group,NEC stageⅠgroup,NEC stageⅡgroup and NEC stageⅢ group,however,the negative rate of HCMV-IgM/IgG had a decrease tendency in the four groups (P <0.05). There were significant differences in the spositive rates of HCMV-PP65,HCMV-IgM,HCMV-IgG,HCMV-IgM/IgG and negative rate of HCMV-IgM/IgG among the four groups (P<0.05).Moreover 82 patients were survived and 21 patients died.The single factor and multiple factors Logistic regression analysis showed that positive HCMV IgG and negative HCMV IgM/IgG were protective factors of prognosis of premature infants with NEC (P<0.05). However positive HCMV-PP65,positive HCMV-IgM and HCMV-IgM/IgG were risk factors of premature infants with NEC(P<0.05).Conclusion HCMV infection may play an important role in pathogenesis, progression and poor prognosis of preterm infants with NEC.