Effects of human mycoplasma and cytomegalovirus infection on pregnancy outcome

JIANG Guohua; WU Xuanhua

doi:10.3969/j.issn.1002-7386.2018.09.002

Abstract：Objective To investigate the effects of human mycoplasma and cytomegalovirus infection on pregnancy outcome.Methods The prevalences of human mycoplasma and cytomegalovirus infection in 200 pregnant women and their neonates were prospectively evaluated. The polymerase chain reaction was used to detect the bacterial and viral STI pathogens in vaginal swabs of pregnant women and oral swabs of newborns. A standardized questionnaire about prepregnancy and current pregnancy was instituted, moreover, the linear regression analysis was used to analyze the correlation between pathogen detection and pregnancy outcome.Results The ureaplasma was the most common pathogen in the detection with positive rate being 90.5% in preganant women and 47.5% in neonates, followed by mycoplasma (32.5% and 7.5%,respectively), chlamydia (14.5% and 7.5%), trichomonas (8.5% and 4.0%) and neisseria gonorrhoeae (0.5% and 0). CMV was found in 46.5% of pregnant women and 10.5% of newborns, HSV-2 was found only in two mothers. Conclusion The multiple regression analysis showes that the maternal colonization of ureaplasma urealyticum,human mycoplasma,trichomonas vaginalis or CMV is associated with the vertical transmission of neonates,moreover,the transmission of human mycoplasma or CMV from pregnant women to future generations is associated with the decrease of neonatal body length and gestational age. Therefore,the diagnostic detection should be performed in clinical practice.