Stduy on inflammatory factors, oxidative stress and thioredoxin interacting protein in patients with type 2 diabetes mellitus complicated by non alcoholic fatty liver
Abstract：Objective To investigate the levels of inflammatory factors, oxidative stress and thioredoxin interacting protein (TXNIP) in patients with type 2 diabetes mellitus complicated by non alcoholic fatty liver, and to explore their correlation.Methods A total of 102 patients with non-alcoholic fatty liver were divided into normal blood glucose group (fasting blood glucose <6.1 mmol/L, and postprandial blood glucose <7.8mmol/L), abnormal glucose tolerance group (fasting blood glucose 6.1 ~6.9mmol/L, or 2h postprandial blood glucose 7.8 ~11.0mmol/L), type 2 diabetes group (fasting blood glucose ≥7. 0mmol/L, and 2h postprandial blood glucose≥11. 1mmol/L). The levels of inflammatory cytokines including C reaction protein(CRP),interleukin 1β(IL-1β),interleukin 6(IL-6),tumor necrosis factor α(TNF-α),and adiponectin and oxidative stress indexes including reduced glutathione (GSH), superoxide dismutase (T-SOD), glutathione peroxidase (GSH-Px), catalase (CAT) as well as TXNIP levels were observed and compared among the three groups. Results The levels of CRP,IL 1β,IL-6 and TNF-α in abnormal glucose tolerance group and type 2 diabetes group were significantly higher than those in normal blood glucose group,however, the adiponectin levels were significantly lower than those in normal blood glucose group (P<0.05).The levels of CRP, IL-1β, IL-6 and TNF-α in type 2diabetes group were significantly higher than those in normal blood glucose group and abnormal glucose olerance group,but adiponectin levels were significantly lower than those in normal glucose group and abnormal glucose tolerancegroup (P<0.05).There were no significant differences in IL1β levels between normal blood glucose group and abnormal glucose tolerance group(P>0.05). Moreover GSH levels in abnormal glucose tolerance group and type 2 diabetes group were significantly higher than those in normal blood glucose group,however,the levels of T-SOD,GSH-Px and CAT were significantly lower than those in normal blood glucose group(P<0.05).The levels of T-SOD,GSH-Px and CAT in type 2 diabetes group were significantly lower than those in abnormal glucose tolerance group(P<0.05),but there were no significant differences in GSH levels between the two groups (P>0.05). In addition the TXNIP levels in abnormal glucose tolerance group and type 2 diabetes mellitus group were significantly higher than those in normal blood glucose group, and TXNIP level in type 2 diabetes group were significantly higher than those in abnormal glucose tolerance group (P<0.05). Pearson correlation analysis showed that TXNIP levels were positively correlated with those of CRP,IL-6,TNF-α and GSH,however,which were negatively correlated with those of adiponectin,T-SOD,GSH-Px and CAT (P <0.05). The multiple linear stepwise regression analysis by using TXNIP as dependent variables,taking CRP, IL-6, TNF-α, GSH, adiponectin, T-SOD, GSH-Px and CAT as independent variables showed that TXNIP levels were positively correlated with those of CRP,IL-6 and TNF-α(P<0.05) after eliminating multiple factors interaction effect. Conclusion The patients with non-alcoholic fatty liver complicated by abnormal glucose tolerance and the patients with type 2 diabetes mellitus have obvious inflammatory reactions and oxidative stress injury. TXNIP may be involved in the pathogenetic process of type 2 diabetes mellitus combined with non-alcoholic fatty liver.
Keywords：diabetes mellitustype 2fatty livernon-alcoholicinflammatory factorsoxidative stressthioredoxin interacting protein
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1285-1289 )