Clinical application of carboprost trometamol injection combined with intrauterine plugging with iodoform gauze in patients with postpartum hemorrhage due to placenta previa

doi:10.3969/j.issn.1002-7386.2018.08.020

Abstract：Objective To investigate the clinical application of carboprost trometamol injection combined with intrauterine plugging with iodoform gauze in patients with postpartum hemorrhage due to placenta previa.Methods A total of 120 patients with postpartum hemorrhage due to placenta previa who underwent cesarean section in our hospital from January 2012 to January 2016 were randomly divided into observation group(n=60) and control group(n=60) according to random number table.The patients in observation group were treated by injecting into uterine musculature carboprost tromethamine 250μg and oxytocin 30 units after delivery,with oxytocin 10 units being infused by intravenous drip. The placenta was delivered slowly after being peeled off. If the uterine bleeded violently,suturing in"8"or"U"shape with absorbable suture to stop bleeding. Once the situation was obviously improved, linking iodoform gauze and plugging it in the lower uterine segment.However the patients in control group were treated by injecting into uterine musculature 30 units of oxytocin, with other 10 units being infused by intravenous drip,at the same time, taking sublingual misoprostol for 200μg. Then the postpartum hemorrhage volume, puerperal infection rate, hysterectomy rate, operation time and adverse drug reactions were compared and compared between two groups.Results After treatment, the intraoperative hemorrhage volume in observation group was (1,076.75 ± 256.22)ml,and (1,224.67 ± 104.15)ml at 24 hours after delivery, which was significantly lower than those in control group (P<0.05). The puerperal infection rate, hysterectomy rate and operation time in observation group were significantly lower than those in control group (P <0. 05). However there was no significant difference in incidence rate of adverse reactions between two groups (P>0.05).Conclusion The combination application of carboprost trometamol and intrauterine plugging with iodoform gauze has obvious therapeutic effects on postpartum hemorrhage due to placenta previa,which can reduce postpartum hemorrhage, avoid hysterectomy, decrease puerperal infection rate, save operation time,save blood source and reduce hospital costs,therefor,which is worth using widely in clinical practice.