Expression and clinical significance of VEGF and MMP-9 in endometrial carcinoma
GAN Lu
CHEN Yan
JV Wenhui
Abstract：Objective To investigate the expression and clinical significance of vascular endothelial growth factor (VEGF) and matrix matalloproteinase (MMP-9) in patients with endometrial carcinoma.Methods One hundred patients with endometrial carcinoma who were admitted and treated in our hospital from January 2014 to February 2017 were enrolled as observation group,at the same time,the other 100 patients with benign uterus diseases who underwent surgical treatment were enrolled as control group. After admission,all the patients were examined completely,and the perioperative resected lesion tissues slices were prepared.Immunohistochemistry was used to detect the expression levels of VEGF and MMP-9 protein,and the examination results and clinicopathological features were analyzed by single factor and multi-factor Logistic regression analysis.Results There were no significant differences in the positive rates of VEGF and MMP-9 in paracancerous tissues of observation group and control group (P>0.05).However the positive rates of VEGF and MMP-9 in endometrial carcinoma tissues were significantly higher than those in paracancerous tissues(P<0.05).The single factor analysis results showed that the positive rates of VEGF and MMP-9 protein in endometrial carcinoma were not correlated with patient's age,tumor size and differentiation degree of tumor (P >0. 05),however,which were closely correlated to tumor invasion depth,lymph node metastasis and pathological stage (P<0.05).Moreover the multivariate Logistic regression analysis showed that the positive rates of VEGF and MMP-9 in endometrial carcinoma were closely correlated with the depth of invasion,lymph node metastasis and Dukes stage in endometrial carcinoma (P <0.05). Conclusion The overexpression of VEGF and MMP-9 exists in patients with endometrial carcinoma,which is closely correlated with the tumor tissue infiltration,lymph node metastasis and clinical stage,which can directly participate in the occurrence and development of endometrial cancer.
Keywords：vascular endothelial growth factormatrix matalloproteinaseimmunohistochemistryendometrial cancerclinical significance
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1168-1171 )