Clinical application of color Doppler ultrasound combined with different kinds of tumor markers detection in early diagnosis of ovarian cancer
Abstract：Objective To investiigate the clinical value of color Doppler ultrasound combined with CA125,HE4 and AFP detection in early diagnosis of ovarian cancer. Methods A total of 307 patients with ovarian neoplasms who were diagnosed definitely in our hospital from January 2013 to January 2015,including 63 cases of ovarian malignant tumors and 244 cases of ovarian benign tumors.were enrolled in the study. The results of ultrasound and detection of serum levels of CA125, HE4 and AFP were analyzed,and the diagnostic value of color Doppler ultrasound and detection of different kinds of tumor markers in early diagnosis of ovarian cancer was compared. Results The color Doppler ultrasound showed there were significant differences in shape,location,texture,blood flow,nipple and ascites between benign ovarian tumors and malignant ovarian tumors(P<0.05). There were significant differences in the serum levels of CA125 and HE4 between benign ovarian tumors and malignant ovarian tumors (P<0.05).The serum levels of CA125 and HE4 were significantly increased with the increase of malignant degree(P<0.05).In the combined detection,color Doppler ultrasonography + CA125 + HE4 + AFP was the optimized combination detection method,with higher sensitivity(95.24%) and specificity(90.98%).Conclusion The color Doppler ultrasound combined with different kinds of tumor markers dtection in early diagnosis of ovarian cancer have has higher sensitivity,specificity and test coincidence rate, which can make up the bias caused by subjective and objective causes to improve the early diagnosis levels for ovarian cancer.
Keywords：color Doppler ultrasoundtumor markersovarian cancerearly diagnosis
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1144-1147 )