Analysis of the effects of rhGH combined with double stimulation therapy on serum hormones and immunological indexes in patients with hypofunction of ovary
Abstract：Objective To investigate the effects of recombinant human growth hormone (rhGH) combined with double stimulation therapy on serum hormones and immunological indexes in patients with hypofunction of ovary.Methods A total of 176 patients with hypofunction of ovary were randomly divided into study group(n=88) and control group(n=88). The patients in study group were treated by recombinant human growth hormone (rhGH) combined with double stimulation, however,the patients in control group were treated by double stimulation only. The curative effects,complications,the changes of serum levels of estradiol (E2), follicle stimulating hormone (FSH),luteinizing hormone (LH), and serum levels of antiovarian antibodies (AOAb),anticardiolipin antibody (ACA), thyroglobulin antibody (TG-Ab), anti white endometrial antibody (EmAb) and antisperm antibody (ASA) were observed and compared between two groups. Results The total effective rate in study group was 90.14%,which was significantly higher than(68.18%) in control group(P<0.05).After treatment,the serum levels of FSH, LH and E2 in study group were significantly improved,as compared with those before treatment (P<0.05),moreover the improvement degree in study group was more obvious than that in control group (P<0.05).After treatment,the positive rates of AOAb,ACA,TG-Ab,EmAb and ASA were decreased in both groups,moreover the decrease degree in study group was more obvious than that in control group (P<0.05). In addition the incidence rate of adverse reactions in study group was 5.68%,which was significantly lower than that(12.50%) in control group(P<0.05). Conclusion The rhGH combined with double stimulation has obvious curative effects on hypofunction of ovary,which can effectively reduce complications, improve serum hormone levels and related immunological indexes,with good clinical application value,therefor,which is worth further popularization and application.
Keywords：recombinant human growth hormonedouble stimulations therapyovarian reserve hypofunctionserum hormoneimmunological indexes
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1135-1139 )