The predictive and diagnostic value of the ratio of neutrophil/lymphocyte, platelet/lymphocyte,mean platelet volume,hs-CRP in diabetic retinopathy

LI Jia

doi:10.3969/j.issn.1002-7386.2018.07.019

Abstract：Objective To investigate and compare the predictive and diagnostic value of the ratio of neutrophil/lymphocyte, platelet/lymphocyte,mean platelet volume,hs-CRP in diagnosis of diabetic retinopathy(DR).Methods A total of 390 patients with type 2 diabetes mellitus (T2DM) were divided into NDR group (patients without DR,n=157),NPDR group (patients with non-proliferative DR,n=132) and PDR group (patients with proliferative DR,n=101),moreover the other 110 healthy subjects were enrolled as control group. The levels of neutrophil,lymphocyte,mean platelet volume,hs-CRP, blood lipid and blood glucose were detected and compared among the four groups.Results The levels of NLR,PLR,MPV and hs-CRP in NDR group,NPDR group,PDR group were higher than those in control group, moreover,the levels of NLR,PLR, MPV and hsCRP in NPDR group and PDR group were significantly higher than those in NDR group (P<0.05),however, there were no significant differences in the levels of NLR,PLR,MPV and hs-CRP between NPDR group and PDR group.The Logistic regression analysis showed that after adjusted for patient's age,diabetes duration,blood pressure,BMI,blood lipid,FBG and HbA1c,the NLR,PLR,MPV and hsCRP were all risk factors of DR.The ROC curve analysis showed that the area under curve of MPV was the largest,when its cut off value of DR was set at 10.85fl,sensitivity of diagnosis of DR was 79.70%,with specificity being 64.80%,therefor,MPV was the most suitable predictive index in diagnosis of DR.Conclusion The NLR, PLR,MPV and hs-CRP are all the risk factors of DR,in which MPV has the most significant predictive and diagnostic value for DR,therefor,in clinic for diabetic patients with MPV >10.85fl, who are need to be examined by ophthalmofundoscopy further,which is beneficial to eartly diagnosis and early treatment of DR.