Therapeutic effects western medicine combined with Qingrequshi Hezhongzhixue prescriptions on anaphylactoid purpura in children and its effects on levels of cytokines in peripheral blood of patients

doi:10.3969/j.issn.1002-7386.2018.07.016

Abstract：Objective To investigate the therapeutic effects of western medicine combing Qingrequshi Hezhongzhixue prescriptions on henoch-schonlein purpura (HSP) in children and its effects on levels of cytokines in peripheral blood of patients. Methods A total of 152 children patients with HSP who were treated in our hospital from March 2016 to March 2017 were randomly divided into combination treatment group (n=60) and control group (n=92). The patients in control group were treated by anti-infective,anti-allergy and symptomatic treatment,however,the patients in combination treatment group,on the basis of of control group,were treated by Qingrequshi Hezhongzhixue prescriptions. The therapeutic effects, duration of clinical symptoms, the serum levels of procalcitonin (PCT),C-reactive protein (CRP),IL-8,TNF-α and ICAM before and after treatments were observed and compared between two groups.Results On admission there were no significant differences in patient's gender and age,clinical symptoms and serum levels of IL-8,TNF-α and ICAM between two groups (P>0. 05). After treatment,the serum levels of CRP,IL-8,TNF-α and ICAM in combination treatment group were significantly lower than those in control group (P <0.05 or P <0.01). Moreover the duration of clinical symptoms in combination treatment group was significantly shorter than that in control group(P<0.05),and the total effective rate(95%) in combination treatment group was significantly higher than that (88.04%) in control group (P <0.05).In additon the excellence eare and effective rate in combination treatment group were significantly higher than those in control group (P<0.05).Conclusion The western medicine combined with Qingrequshi Hezhongzhixue prescriptions in treatment of HSP can improve therapeutic effects and decrease the serum levels of CRP,IL-8,TNF-α,ICAM,which can also shorten duration of clinical symptoms,therefor,which is worth using widely in clinical;practice.