Therapeutic effects and safety of liraglutide combined with insulin in treatment of type 2 diabetes mellitus
Abstract：Objective To evaluate the therapeutic effects and safety of liraglutide combined with insulin in treatment of type 2 diabetes mellitus through blood glucose monitoring.Methods Forty patients with type 2 diabetes mellitus who were treated in our hospital from April 2016 to April 2017 were randomly divided into combination treatment group (liraglutide+insulin) and ximple insulin treatment group. The blood glucose indexes including blood glucose fluctuations,the absolute difference of daytime blood sugar,the highest extent of blood sugar,postprandial blood glucose range, fasting blood glucose, postprandial 2h blood glucose,glycated hemoglobin before treatment,during treatment, at 3 months after treatment were observed and compared between two groups.Results After 3-month treatment,there were no significant differences in the levels of fasting blood glucose,glycated hemoglobin,2h postprandial blood glucose between two groups(P>0.05). However there were significant differences in blood glucose fluctuations,the absolute difference of daytime blood sugar,the highest extent of blood sugar,postprandial blood glucose range between two groups (P<0.05).Conclusion The liraglutide combined with insulin can effectively control blood sugar in patients with type 2 diabetes mellitus,and can reduce blood sugar fluctuations, decrease the incidence of hypoglycemia so as to increase security in treatment of type 2 diabetes mellitus.
Keywords：insulintype 2 diabetesliraglutideblood glucose monitoring
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1016-1019 )