Clinical comparative analysis of laparoscopic surgery and laparotomy in treatment of endometrial cancer
Abstract：Objective To investigate the clinical curative effects of laparoscopic surgery and laparotomy in treatment of endometrial cancer (EC). Methods According to different surgical methods,140 patients with EC were divided into laparoscopic surgery group(laparoscopic group) and traditional laparotomy surgery group(laparotomy group),with 70 patients in each group.The intraoperative bleeding volume,the numbers of cleanin lymph nodes, operation time,drainage volume of pelvic cavity and abdominal cavity,the time of anal exhaust,use of analgesics after operation,the time of getting out of bed, indwelling time of catheter after operation,the postoperative hospitalization duration,the incidence rate of postoperative complications,the recurrence and metastasis during follow-up,the serum levels of tumor markers-HE4,CA125 and immunological function indexes including IgG and CD4/CD8 before and after operation were observed and compared between two groups.Results There were no significant differences in the numbers of cleaning lympho nodes between two groups(P>0.05).The intraoperative bleeding volume,operation time,drainage volume of pelvic cavity and abdominal cavity,the time of anal exhaust,use of analgesics after operation,the time of getting out of bed,indwelling time of catheter after operation and hospitalization time in laparoscopic group were superior to those in laparotomy group (P <0.05). The incidence rate of complications in laparoscopic group was 10.00%,which was significantly lower than that(25.715) in laparotomy group(P<0.05). There were no significant differences in distal metastasis and local recurrence between two groups (P >0.05). Besides,the serum levels of HE4 and CA125 were significantly decreased after operation in both groups(P<0.05),moreover the decrease degree in laparoscopic group was more obvious than that in laparotomy group(P<0.05).Moreover the levels of IgG and CD4/CD8 were significantly decreased in both groups, as compared with those before operation,moreover,the decrease degree in laparoscopic group was more obvious than that in laparotomy group (P <0.05). In addition the serum levels of IgG and CD4/CD8 were significantly decreased after operation in both groups(P<0.05),moreover the improvement degree of IgG,CD4/CD8 levels in laparoscopic group was superior to that in laparotomy group(P<0.05).Conclusion The laparoscopic surgery can achieve the same curative effects as laparotomy does,and it has the advantages of less trauma,less intraoperative bleeding volume,quick recovery,shorter hospital stay and lower incidence rate of complication,therefor,which is worth using widely in clinical practice.
Keywords：laparoscopelaparotomyendometrial cancerclinical contrast
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 974-977 )