Clinical significance and expression of miR-30 in patients with gastric cancer

doi:10.3969/j.issn.1002-7386.2018.06.012

Abstract：Objective To explore the expression and clinical significance of miR30 in patients with gastric cancer. Methods The gastric cancer tissues and adjacent tissues of eighty patients with gastric cancer were collected, at the same time,the peripheral blood specimens of patients with gastric cancer and 40 healthy subjects who received physical examination were collected. The expressions levels of miR30 were detected by Real-time RT-PCR, and the correlation between the expression levels of miR30 and clinicopathological characteristics of gastric cancer was analyzed by means of Pearson analysis. Results The expression levels of miR30 in gastric cancer tissues (16.82 ± 2.41) were significantly lower than those in adjacent tissues(4.57 ± 1.24) ( P <0.01).The expression levels of miR30 were not correlated with patient's gender,age, tumor size and differentiation degree ( P >0.05),however,which were related with clinical stage and lymphatic metastasis (P<0.05 or P <0. 01). The expression levels of miR30 in peripheral blood of patients with gastric cancer were also significantly lower than those of healthy subjects( P <0.05),moreover,which were positively correlated with those in gastric cancer tissue ( r = 0.832,P <0.01).Conclusion MiR30 is associated with clinical stage and lymph node metastasis, which is a potential target for the treatment of gastric cancer.