The reliability of early screening of tumor markers including TK1,CEA and AFP in diagnosis of malignant tumors
JIANG Xiaorong
WANG Yu
WANG Shasha
Abstract：Objective To investigate the reliability of early screening of tumor markers including thymidine kinase 1 (TK1),carcinoembryonic antigen(CEA) and alpha fetoprotein(AFP) in diagnosis of malignant tumors.Methods The data about 486,085 subjects who underwent routine medical examination in our Health Center from 2009 to 2014 were retrospectively analyzed,in whom 56,286 subjects received malignant tumor markers screening. The concentrations of CEA and AFP were dtected by electrochemiluminescence immunoassay,and STK1 levels were measured by commercial kit based on an enhanced chemiluminescence dot blot assay. Results The incidence rate of malignant tumors was increased from 48.3/100,000 to 220.3/100,000.The three kinds of tumors with higher incidence rate were liver cancer, cervical cancer and lung cancer, respectively. Moreover STK1 was correlated to tumor growth rate,which was more sensitive than CEA and AFP in diagnosis of malignant tumors and in evaluation of patient's prognosis.Besides STK1 was also regarded as a prognostic biomarker and could be used for postoperative follow up of patients for 10 ~40 months, but CEA and AFP had no significance of follow up. Conclusion STK1 is a reliable biomarker to discover malignant tumors in tumor screening.
Keywords：serum thymidine kinase 1carcinoembryonic antigenalpha fetoproteinmedical examination screeningmalignant tumor
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 819-822 )