Effects of laparoscopic radical operation on anorectal dynamics and serum levels of vascular endothelial growth factor C in patients with colorectal cancer
JIANG Xinlin
Abstract：Objective To observe the effects of laparoscopic radical operation on anorectal dynamics and serum levels of vascular endothelial growth factor C (VEGF-C) in patients with colorectal cancer.Methods One hundred patients with colorectal cancer who were admitted and treated in our hospital from December 2011 to December 2015 were randomly divided into open abdomen group and laparoscope group, with 50 patients in each group.The patients in open abdomen group were treated by open abdomen radical operation,however,the patients in laparoscope group were treated by laparoscopic radical operation.The curative effects,the changes of anorectal dynamics, serum levels of VEGF-C before and after operation were statistically analyzed and compared between two groups. Results The intraoperative bleeding volume, exhaust time, hospitalization time,incidence rate of complication in laparoscope group were significantly lower than those in open abdomen group (P<0.05),however, the operation time in the former was significantly longer than that in the latter (P <0.05), moreover,there were no significant differences in 1-year relapse rate and fatality rate between two groups (P>0.05).The anal canal high pressure zone length(HPZ),anal rest pressure(ARP),maximal squeezing pressure(MSP) and serum levels of VEGF-C on 3d,7d after operation were significantly decreased in both groups, as compared with those before operation, moreover,after operation the levels of HPZ, ARP, MSP in laparoscope group were significantly higher than those in open abdomen group,however,the serum levels of VEGF-C on 3d,7d after operation were significantly lower than those in open abdomen group (P<0.05).Conclusion The laparoscopic radical operation can effectively reduce the intraoperative trauma of patients with rectal cancer,decrease postoperative complications,which is beneficial to anorectal dynamic recovery,without increaing the risks of relapse,metastasis,death occurrence,but it is required to improve the relevant operation technique.
Keywords：laparoscopic radical operationcolorectal canceranorectal dynamicsvascular endothelial growth factor C
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 721-724 )