Effects of cryoablation combined with sorafenib and interleukin-2 on immune function of patients with advanced metastatic renal cell carcinoma
Abstract：Objective To observe the effects of cryoablation combined with sorafenib and interleukin-2 (IL-2) on immune function of patients with advanced metastatic renal cell carcinoma.Methods A total of 90 patients with advanced metastatic renal cell carcinoma who were admitted and treated in our hospital from October 2013 to October 2016 were enrolled in the study. These patients were randomly divided into observation group(n=45) and control group(n=45). The patients in control group were treated by oral sorafenib tosylate tablets and intravenous drip with recombinant human interleukin-2, however,the patients in observation group were treated firstly by cryoablation under local anesthesia for two weeks,then these patients were treated by oral sorafenib tosylate tablets and intravenous drip with recombinant human interleukin-2,with a treatment course of 4 weeks for both groups. The serum levels of alpha-fetoprotein (AFP), H-subunit ferritin (HF), carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA199) before and after treatment were measured by MEIA,and the proportions of T lymphocytes(CD+3,CD+4,CD+8,CD+4/CD+8,CD+19,CD+16+56),NK cells and Treg cells were detected by flow cytometry. Moreover the serum levels of IgA,IgG and IgM were measured by immunoturbidimetry.Results There were no significant differences in the levels of AFP, HF, CEA, CA199, CD+3, CD+4, CD+8, CD+4/CD+8, CD+19, CD+16+56,NK cells and Treg cells,IgA,IgG,IgM in control group before and after treatment (P>0.05). As compared with those before treatment,the proportions of CD+3,CD+4,CD+4/CD+8,CD+19,CD+16+56 and levels of NK cells and IgA,IgG,IgM were significantly increased in observation group after treatment,however,the levels of AFP, HF, CEA, CA199 and the proportions of CD+8 and Treg cells were significantly decreased in observation group after treatment(P<0.05).Conclusion The cryoablation combined with sorafenib and interleukin-2 in treatment of advanced metastatic renal cell carcinoma can significantly improve the mmune function of patients and strengthen the anti-tumor immune response.
Keywords：cryoablationsorafenibrecombinant human interleukin-2 for injectionadvanced metastatic renal cell carcinomaimmune functionT lymphocyte
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 677-680 )