Study on the efficacy and safety of the Qi-ming granule combined with laser treating on macular edema of diabetic retinopathy

doi:10.3969/j.issn.1002-7386.2018.04.019

Abstract：Objective To study the efficacy and safety of the Qi-ming granule combined with laser treating on macular edema of diabetic retinopathy.Methods Patients were randomly divided into treatment group (51 patients with 72 studied eyes) and control group(50 patients with 69 studied eyes). Both groups were given photo-coagulation treatment while the treatment group was additionally given the Qi-ming granule. To observe the changes of the intraocular pressure, best corrected vision and the thickness of the central fovea of macula, at the same time detect the adverse effect.Results There were no significant differences between the two groups in intraocular pressure before and after therapy(P>0.05). The average value of BVCA and CMT in two groups both significantly increased after 1,3 months therapy (P<0.05); Compared in the two groups,the differences were statistically significant (P<0.05). The amplitude density of a-wave and b-wave at macular area in two groups were statistically larger after 3 months treatment (P<0.05).There were statistical differences in the two treatment groups(P<0.05). During the treatments,2 patients (2.78%) suffered from stomach discomfort,while both were spontaneous remission without any therapeutic measure,there were no adverse effect and sequela occurred in other patients. Conclusion Compared with the traditional laser treatment, the treatment of combined the Qi-ming granule with laser has a better effect on treating macular edema of diabetic retinopathy,it is worth of clinical application for highly improving the visual acuity and consolidating the therapeutic effect with high safety.