Clinical curative effects of captopril combined with felodipine sustained-release tablets on blood pressure variability in elderly patients with essential hypertension

ZHOU Jingjing; MA Xiaochun

doi:10.3969/j.issn.1002-7386.2018.04.005

Abstract：Objective To investigate the curative effects of captopril combined with felodipine sustained-release tablets on essential hypertension in the eldrly,and to observe its efffects on blood pressure variability(BPV).Methods One hundred and forty-four elderly patients with essential hypertension who were treated in our hospital from June 2015 to December 2016 were enrolled in the study. According to the order of hospitalization,these patients were randomly divided into observation group and control group,with 72 patients in each group. The patients in control group were treated by captopril combined with hydrochlorothiazide,however,the patients in observation group were treated by captopril combined with felodipine sustained release tablets.The ambulatory blood pressure in 24 hours,and the changes of BPV before treatment and on 6w,12w after treatment, the therapeutic effects and the changes of glucose and lipid metabolism, indexes of liver and kidney function before and after treatment,the adverse reactions during treatment were statistically analyzed and compared between two groups.Results At 6 weeks and 12 weeks after treatment,the 24 hours mean systolic blood pressure (SBP),d SBP,n SBP,morning peak SBP, 24h systolic blood pressure variability (SBPV), 24h DBPV, d SBPV and d DBPV were significantly decreased in both groups,as compared with those before treatment(P<0.01). The 24h DBP and the d DBP after 12-week treatment in observation group were significant lower than those before treatment (P<0.05). As compared with those in control group,the 24h SBP,d SBP,n SBP,morning peak SBP and DBP were significantly decreased in observation group on 6w,12w after treatment(P<0.05). On 12w after treatment,the 24h SBPV,24h DBPV,d SBPV and d DBPV were significantly decreased in observation group,as compared with those in control group (P <0.05 or P <0.01). The total effective rates in observation group and control group were 86. 11% and 93. 06% respectively, there was a significant difference between two groups(χ2= 1.860,P>0.05). However there were no significant differences in blood glucose,blood lipid,liver and kidney functions before and after treatment between two groups,moreover,there was no significant difference in incidence rate of adverse reactions between two groups(χ2=0.067,P>0.05).Conclusion The felodipine sustained - release tablets combined with captopril can effectively reduce the blood pressure in elderly patients with essential hypertension,moreover, which can control BPV,without affecting glycolipid metabolism,liver and kidney functions,therefor,which is a safe and effective treatment scheme.