Therapeutic effects of flupentixol and melitracen combined with Saccharomyces boulardii on diarrhea-predominant irritable bowel syndrome complicated by anxiety and depression

WANG Dan; ZHANG Lili

doi:10.3969/j.issn.1002-7386.2018.04.004

Abstract：Objective To observe the therapeutic effects of flupentixol and melitracen tablets combined with Saccharomyces boulardii on diarrhea-predominant irritable bowel syndrome (IBS) complicated by anxiety and depression. Methods A total of 120 patients with diarrhea-predominant IBS complicated by anxiety and depression who were admitted and treated in our hospital from January 2013 to January 2015 were randomly divided into two groups, combination treatment group and control group, with 60 patients in each group. The oatients in combination treatment group were treated by flupentixol and melitracen tablets combined with oral Saccharomyces boulardii,however,the patients in control group were treated only by taking orally Sccharomyces boulardii,with a treatment course of 4 weeks for both groups. The gastrointestinal symptoms and mood disorders before treatment and on 1w,4w after treatment were observed and compsred between two groups, moreover, the incidence rates of adverse reactions were also observed and statistically analyzed. Results There was no significant difference in the effective rate of gastrointestinal symptoms improvement after 1-week treatment between control group and combination treatment group [23.3%(14/60) vs 31.7%(19/60),P>0.05]. The effective rates of Hamilton's depression scale (HAMD) scores improvement in control group and combination treatment group were 11.8%(6/51) and 33.3%(19/57),respectively,and the effective rates of symptom improvement according to Hamilton's anxiety scale (HAMA) scores in control group and combination treatment group were 16.1%(9/56) and 35.6%(21/59),respectively, there were significant differences between two groups (P <0.01). Moreover after 4-week treatment the effective rates of gastrointestinal symptoms improvement in combination treatment group patients was 93.0% (53/57),which was significantly higher than that[74.1% (43/58)] in control group(P<0.01). The effective rates of HAMD scores improvement in control group and combination treatment group were 34.7% (17/49) and 64.8%(35/54),respectively, there were significant differences between two groups(P<0.01).The effective rate of symptom improvement according to HAMA scores in combination group was 80.4%(45/56),which was significantly higher than that [35.2%(19/54)] in control group (P<0.01). After 1-week treatment,the incidence rate of adverse reactions was 5.0%(3/60)in both groups,and after 4-week treatment, the incidence rates of adverse reactions in combination treatment group and control group were 3.5%(2/57)and 3.4%(2/58),respectively,there were no significant differences in incidence rates of adverse reactions in the two time points between two groups (P>0.05).Conclusion Flupentixol and melitracen combined with saccharomyces boulardii treatment could not only improve the anxiety and depression symptoms of patients with diarrhea predominant IBS,but also effectively improve gastrointestinal symptoms of the patients. The efficient of combined treatment is better than monotherapy saccharomyces boulardii alone treatment.