Study on the correlation between serum levels of alveolar surface active substance protein-D and acute lung injury score in children patients with acute lung injury

CHEN Qinghai

doi:10.3969/j.issn.1002-7386.2018.04.003

Abstract：Objective To investigate the correlation between serum levels of alveolar surface active substance protein-D (SP-D) and acute lung injury score in children patients with acute lung injury (ALI) in order to provide basis for the prognosis of patients with ALI.Methods The 30 healthy children (control group)and 67 children patients with ALI (ALI group) were enrolled in the study. The serum levels of SP-D on admission and on 1d,3d,5d,7d,14d after hospitalization were detected by ELISA,at the same time,acute lung injury score was performed for children with ALI.Moreover the patients with ALI were redivided into ALI without MOF group(ALI without multiple organ failure) and ALI with MOF group(ALI with MOF) according to the severity of ALI. In addition the patients with ALI were divided into survival case group and death case group according to the prognosis of patients.Results As compared with those in control group, the serum levels of SP-D on admission in ALI group were significantly increased (P<0.05).There were significant differences in serum levels of SP-D and acute lung injury score between ALI without MOF group and ALI with MOF group and between survival case group and death case group (P<0.05). Moreover the dynamic changes of serum levels of SP-D and the serum levels of SP-D reached peak on 5d after hospitalization,however acute lung injury score reached peak on 1d after hospitalization,then which were gradually decreased. In addition the serum levels of SP-D in different disease severity degrees and different prognoses of patients on adlission were positively correlated with acute lung injury scores(P<0.05),however,the serum levels of SP-D in different time points were not correlated with acute lung injury scores(P>0.05).Conclusion The serum levels of SP-D are increased after acute lung injury in children,moreover,the increase degree of SP-D levels can reflect the severity of early lung injury,and the serum levels of SP-D are correlated with acute lung injury scores at some extent.