Therapeutc effects of Sanxianbushen prescription on diabetic renal failure after dialysis

LI Nana; LI Limin; ZHANG Zheng

doi:10.3969/j.issn.1002-7386.2018.03.020

Abstract：Objective To investigate the therapeutc effects of Sanxianbushen prescription on diabetic renal failure after dialysis in order to improve prognosis,prolong the life cycle and improve life quality of patients.Methods A total of 98 patients with diabetic renal failure who were treated in our hospital from October 2015 to October 2016 were randomly divided into two groups,control group and observation group,with 49 patients in each group.The patients in control group were treated by maintenance hemodialysis combined with routine western drugs,however,the patients in observation group,on the basis of control group,were treated by Sanxianbushen prescription.The clinical curative effects,renal function indexes,blood glucose levels,blood fat indexes,the improvement status of TCM syndromes,nutritional status and adverse reactions were observed and compared between two groups.Results There were 24 cases with obvious curative effects,20 cases with effectiveness,5 cases without effectiveness in observation group,with effective rate being 89.80％,however,there were 16 cases with obvious curative effects,15 cases with effectiveness,18 cases without effectiveness in control group,with effective rate being 63.27％,the curative effects in observation group were superior to those in control group (P ＜ 0.05).After treatment,the urea nitrogen (BUN),blood creatinine (Scr) and creatinine clearance rate (Ccr) were significantly improved in observation grouo,as compared with those in control group (P ＜0.05).Moreover the fasting blood glucose (FBG),2h blood glucose (2hPG),cholesterol (TC) and triglyceride (TG) were significantly improved in observation group,as compared with those in control group (P ＜ 0.05).The symptom scores of shortness of breath,lazy speech,dizziness headache,less diet,anorexia,spontaneous perspiration in observation group were significantly lower than those in control group (P ＜ 0.05),but there were no significant differences in the symptom scores of squamous and dry skin,limbs numbness,constipation between two groups (P ＞0.05).In addition the levels of red blood cells (RBC),hemoglobin (HGB),serum total protein (TP),serum albumin (propagated) in observation group were significantly higher than those in control group (P ＜ 0.05);After treatment,the blood and urine routine rest,liver and kidney function,electrolyte were not significantly changed in both groups (P ＞ 0.05).Conclusion Sanxianbushen prescription has obvious therapeutic effects on diabetic renal failure after dialysis,which can effective relieve clinical symptoms,promote the improvement of blood glucose and renal function indexes,improve the body's nutritional status,with safety.