Clinical significance of evaluation of current perception threshold in early diagnosis and intervention of type 2 diabetic peripheral neuropathy
Abstract：Objective To detect current perception threshold (CPT) of patients with type 2 diabetes mellitus to screen out the patients with early diabetic peripheral neuropathy (DPN),and to analyze the severity of large and small fiber nerve damage in order to provide theoretical basis for early diagnosis and intervention of DPN.Methods A total of 130 patients with type 2 diabetes mellitus were enrolled in the study.The serum levels of TC,TG,HDL,LDL,FBG,HbA1 c were detected,and sensory nerve was quantitatively detected.Moreover the CPT value in four limbs at 2,000Hz,250Hz,5Hz were measured.Accoeding to CPT,these patients were divided into two groups:normal CPT group and abnormal CPT group.Then the blood lipid levels,glycometabolism parameters and CPT value were observed and compared between two groups to analyze the influencing factors on early DPN.Results Among 130 patients,85 patients had sensory nerve damages,and the levels of BMI,TC,LDL,FBG,HbA1c in sensory nerve damage group were significantly higher than those in control group (P ＜0.05 or P ＜ 0.01),moreover the CPT values in four limbs at 250Hz and 5Hz frequency were significantly higher than those in control group (P ＜0.01).Binary Logistic regression analysis showed that TC and HbA1c were independently related to the DPN (OR =45.052,13.499,respectively,P ＜ 0.01).Conclusion The CPT detection can early find out sensory nerve damages of patients with type 2 diabetes mellitus,which often display damages of small fiber nerve.Moreover the higher levels of TC and HbA1c are independent risk factors of early DPN.
Keywords：current perception thresholdtype 2 diabetes mellitusearly perioddiabetic peripheral neuropathy
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 376-379 )