Analysis for the detection of hemoglobin by capillary electrophoresis in patients with iron deficiency anemia

doi:10.3969/j.issn.1002-7386.2018.03.012

Abstract：Objective To analyze the detection results of hemoglobin by capillary electrophoresis in patients with iron deficiency anemia (IDA) in order to provide some ideas for reasonable diagnosis and treatment.Methods Eighty-eight patients with IDA were enrolled as IDA group,at the same time,the other 110 subjects were served as control groups.The MCV,MCH,RDW,Hb,iron metabolism indexes including ferritin and total iron binding capacity were detected and compared between two groups.Results As compared with those in control group,the levels of Hb,MCV,MCH,HCT,erythrocyte fragility,ferritin and HbA2 were significantly decreased in IDA group (P ＜ 0.05),however,the levels of RDW,total iron binding capacity and HbAlc were significantly increased in IDA group (P ＜ 0.05).In addition,the levels of HbA1 c were negatively correlated with those of Hb,ferritin,MCV,MCH,HCT and erythrocyte fragility in IDA group (P ＜ 0.05),however,which were positively correlated with those of total iron binding capacity and RDW (P ＜ 0.05).Moreover the levels of HbA2 were positively correlated with those of Hb,ferritin,MCV,MCH,HCT and erythrocyte fragility (P ＜ 0.05),however,which were negatively correlated with those of total iron binding capacity and RDW (P ＜ 0.05).Conclusion The levels of HbAlc are increased in patients with IDA,moreover,HbAlc and HbA2 are closely correlated to IDA,and the combined detection MCV,RDW,HbAlc and HbA2 can be regarded as the indexes to differentiate different kinds of anemia.