The study of screening sensitive indexes of predicting the curative effects of neoadjuvant chemotherapy in treatment of breast cancer
ZHANG Wenshan
ZHANG Guoshuan
GENG Cuizhi
Abstract：Objective To investigate the expressions of ER,PR,Ki-67,C-erbB-2,VEGF,DBC2 before neoadjuvant chemotherapy in patients with breast cancer,and to explore the correlation between their expression levels and curative effects of neoadjuvant chemotherapy (NAC).Methods Forty-five patients with breast cancer at stage Ⅱ b ～ Ⅲ c who received neoadjuvant chemotherapy were enrolled in the study.The expression levels of ER,PR,Ki-67,C-erbB-2,VEGF and DBC2 were detected by immunohistochemistry before and after neoadjuvant chemotherapy.Results The univariate analysis showed that when the expressions of ER and PR were negative and Ki-67 and VEGF were highly expressed,the pathological complete remission rate after neoadjuvant chemotherapy and the proportion of chemotherapy reaction of grade 4 ～ 5 (MP classification) were significantly higher than those when the expressions of ER and PR were positive and Ki-67 and VEGF were lowly expressed,respectively (P ＜ 0.05).Conclusion The breast cancer patients with negative expressions of ER and PR and high expressions of Ki-67 and VEGF are more sensitive to NAC,thus,which may be regarded as predictive indexes of NAC.
Keywords：breast cancerneoadjuvant chemotherapyimmunohistochemistybiological factors
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 356-360 )