Correlation between serum levels of sP-selectin, sE-selectin and insulin resistance in patients with diabetes mellitus

doi:10.3969/j.issn.1002-7386.2018.03.007

Abstract：Objective To investigate the correlation between serum levels of sP-selectin,sE-selectin and insulin resistance in patients with diabetes mellitus in order to further provide the scientific basis for clinical treatment.Methods A total of 120 patients with diabetes mellitus who were treated in our hospital from January 2015 to January 2016 were enrolled in the study,including 40 patients with prediabetic state (prediabetic state group),40 patients with diabetes mellitus complicated by coronary heart disease (CHD) (diabetes + CHD group),40 patients with simple diabetes (simple diabetes group),at the same time,40 healthy subjects were served as control group.The levels of blood glucose including fasting plasma glucose and glycosylated hemoglobin and blood lipids including cholesterol,triglyceride,high density lipoprotein cholesterol,low density lipoprotein cholesterol were observed and compared among the four groups,moreover,the correlation among fasting insulin,insulin resistance index,soluble P-selectin and soluble E-selectin was analyzed and compared between the four groups.Results The levels of systolic pressure,blood glucose,triglyceride,cholesterol,high density lipoprotein cholesterol,low density lipoprotein cholesterol,fasting insulin,sP-selectin and sE-select in prediabetic state group,simple diabetes group and diabetes + CHD group were obviously higher than those in control group,moreover,which in diabetes + CHD group were significantly higher than those in simple diabetes group,besides,which in simple diabetes were significantly higher than those in prediabetic state group (P ＜ 0.05).The serum levels of sP-selectin were positively correlated with those of fasting blood glucose,fasting insulin,glycosylated hemoglobin,triglyceride and insulin resistance indexes (r =0.04,0.10,0.11,0.59,0.62,respectively,P ＜ 0.05).Moreover the levels of soluble E-selectin were positively correlated to those of fasting blood glucose,fasting insulin,glycosylated hemoglobin,triglyceride and insulin resistance indexes (r =0.16,0.11,0.10,0.42,0.43,respectively,P ＜ 0.05),however,which were negatively correlated with the levels of high density lipoprotein (r =-0.21,P ＜ 0.05).Conclusion The serum levels of sP-selectin and sE-selectin are correlated with insulin levels and insulin resistance in patients with diabetes mellitus,which has a better clinical guidance effect in evaluating patient's condition and pathogenesis of diabetes,therefor,which is worth researching further.