Effects of trigeminy medication therapy on the expression of leukemia inhibitory factor and perinatal outcome in patients with gestational hypertension
Abstract：Objective To investigate the effects of trigeminy medication therapy of magnesium sulfate,nimodipine and labetalol on the expression of leukemia inhibitory factor (LIF) and perinatal outcome in patients with gestational hypertension.Methods A total of 200 patients with gestational hypertension who were treated in our hospital from January 2012 to May 2014 were randomly divided into experimental group (n =100) and control group (n =100).The patients in experimental group were treated by triple therapy of magnesium sulfate injection + nimodipine + labetalol,however,the patients in control group were treated by magnesium sulfate only.The blood pressure levels,the expression levels and perinatal fetus outcome were observed and compared between two groups.Results After treatment,the levels of systolic pressure and diastolic pressure were decreased in both groups,moreover,which in experimental group were significantly lower than those in control group (P ＜ 0.05).The neonatal scores and neonatal body weight in experimental group were superior to those in control group (P ＜ 0.05),moreover,the incidence rate of adverse perinatal birth was significantly lower than that in control group (P ＜ 0.05).After treatment,the levels of LIF were increased in both groups,and the levels of LIF in experimental group were significantly higher than those in control group (P ＜ 0.05).In addition the serum levels of LIF were positively correlated with neonatal scores and neonatal body weight in both groups,however,which were negatively correlated with the outcome of adverse perinatal birth (P ＜ 0.05).Conclusion The trigeminy medication therapy of magnesium + nimodipine + labetalol can effectively treat gestational hypertension by rugulating the expression levels of LIF,with better perinatal outcome,therefor,which is worth using widely in clinical practice.
Keywords：gestational hypertensionleukemia inhibitory factortrigeminy therapyperinatal fetus outcome
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 337-341 )