Effects of intraoperative application of dexmedetomidine on perioperative renal function of patients with diabetes mellitus complicated by acute trauma

doi:10.3969/j.issn.1002-7386.2018.02.003

Abstract：Objective To investigate the effects of intraoperative application of dexmedetomidine on perioperative renal function of patients with diabetes mellitus complicated by acute trauma.Methods Sixty patients with diabetes mellitus (more than 3 years) complicated by acute trauma whose age range was 35 ～ 75 years,body weight 50 ～ 80kg,ASA grade Ⅱ or grade Ⅲ,were randomly divided into dexmedetomidine group (group D) and control group (group C).All the patients were treated by 6-8 hour fasting before operation and were given general anaesthesia,in addition,the patients in group D were given dexmedetomidine 1μg/kg by intravenous pump infusion on 10min before operation,with intravenous pump infusion of dexmedetomidine 0.5 μg · kg-1 · h-1 during operation,however,the patients in group C were given same volume physiological saline.The serum levels of creatinine (Scr),blood urea nitrogen (CysC) and cysteine protease inhibitor C (BUN) before anesthesia (T0),30min after operation (T1),10min before the end of operation (T2),on 1 d (T3),3d (T4),7 d (T5) after operation were detected by radioimmunoassay,in addition the levels of blood glucose (GLU) were detected (enzymology method) and compared between two groups.Results As compared with those in T0,the plasma levels of CysC in group C were significantly increased in T1,T2,T3 (P ＜ 0.05),and the levels of BUN and Scr were increased in T2,T3,T4,moreover,the levels of GLU were increased in T3 in group C (P ＜ 0.05).However the plasma levels of CysC were significantly increased in group D in T1,T2 (P ＜ 0.05),but there were no significant differences in the levels of CysC,BUN,Scr and GLU among the other time points (P ＞ 0.05).As compared with those in group C,the plasma levels of CysC in group D were significantly decreased in T1,T2,T3,and the levels of BUN were significantly decreased in T2,T3,T4,moreover the levels of GLU were significantly decreased in T2,T3 (P ＜ 0.05).Conclusion The intraoperative application of dexmedetomidine has protective effects on perioperative renal function of patients with diabetes mellitus complicated by acute trauma.