The research on the diagnostic value of Fibroscan,APRI and FIB-4 in HBV-related cirrhosis
LIU Nana
HUANG Yi
LIU Huabao
Abstract：Objective To investigate the diagnostic value of Fibroscan,APRI and FIB-4 in patients with hepatitis B virus (HBV) related cirrhosis.Methods A total of 129 patients with HBV-related cirrhosis (cirrhosis group) and 116 patients with chronic hepatitis B (CHB group) who were treated in our hospital from March 2013 to March 2016 were enrolled in the study.The patient's general data and routine laboratory parameters were collected,and APRI and FIB-4 were calculated according to formulas.The levels of Fibroscan were detected and liver stiffness measurement (LSM) was performed.The correlation among clinical parameters was analyzed,and ROC curve was used to evaluate the diagnostic value of LSM,APRI and FIB-4 in differential diagnosis between CHB and HBV-related cirrhosis.Results The levels of LSM,APRI and FIB-4 in cirrhosis group were significandy higher than those in CHB group (P ＜ 0.05).In cirrhosis group,the levels of LSM were positively correlated with those of ALT,AST,APRI and FIB-4 (r =0.241,0.283,0.417,0.485,respectively,P ＜ 0.05),however,which were negatively correlated with those of PLT (r =-0.305,P ＜ 0.05).In CHB group there was no obvious correlation between LSM and the other parameters (P ＞ 0.05).The AUC value of LSM,APRI and FIB-4 in diagnosis of cirrhosis was 0.831 (95％ CI:0.780 ～ 0.881),0.717 (95 ％ CI:0.651 ～ 0.782) and 0.715 (95 ％ CI:0.650 ～ 0.780),respectively.Conclusion The Fibroscan,APRI and FIB-4 can be used to diagnose CHB with less inflammation activity and HBV-related cirrhosis,moreover,the diagnostic value of Fibroscan is superior to that of APRI or FIB-4.
Keywords：cirrhosischronic hepatitis Bfibroscanliver stiffness valueaminotransferse/platelet ratio indexfibrosis index based in the four factors
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 61-64 )