Expressions of MMPs, TIMPs and TLR in the fetal membrane tissues of patients with PROM
NI Suna
LIU Jing
Abstract：Objective To explore the expressions of matrix metalloproteinases (MMPs),tissue inhibitor of metalloproteinase (TIMPs) and Toll like receptor (TLR) in the fetal membrane tissues of patients with premature rupture of membrane (PROM).Methods A total of 60 patients with PROM who were admitted and treated in our hospital from June 2016 to June 2017 were enrolled as observation group,and the other 60 parturients who underwent cesarean section were enrolled as control group.The expression levels of MMP-9,transforming growth factorβ1 (TGF-β1),TIMP-1,TLR-2,TLR-4 were detected by inmunohistochemistry forboth groups.Results The expression levels of MMP-9 in observation group were significantly higher than those in control group,however,the expression levels of TIMP-1 and TGF-β1 were significantly lower than those in control group (P ＜ 0.05).Moreover the expression levels of TLR-2 and TLR-4 in observation group were significantly increasd,as compared with those in control group (P ＜ 0.05).Conclusion TLR-2 and TLR-4 are involved in the pathogenesis of PROM through immune mediation,and the pathogenesis of PROM is correlated with the imbalance of MMP-9/TIMP-1,moreover,TGF-β1 can regulate the expressions of MMP-9 and TIMP-1 to cause the imbalance of MMP-9/ TIMP-1,and to increase the degradation of ECM to result in PROM.
Keywords：matrix metalloproteinasestissue inhibitor of metalloproteinaseToll like receptorpremature rupture of membranes
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 28-31 )