Effects of recombinant human brain natriuretic peptide combined with Shenfu injection on cardiac function and neuroendocrine hormone levels of patients with acute myocardial infarction complicated by pump failure
ZHANG Dacheng
ZHANG Chunyu
LU Mengxi
Abstract：Objective To observe the effects of recombinant human brain natriuretic peptide combined with Shenfu injection on cardiac function and neuroendocrine hormone levels of patients with acute myocardial infarction complicated by pump failure.Methods Seventy patients with acute myocardial infarction combined by pump failure were randomly divided into control group and observation group,with 35 aptients in each group.The patients in control group were treated by conventional treatment,however,the patients in observation group,on the basis of control group,were treated by recombinant human brain natriuretic peptide combined with Shenfu injection.The left ventricular end-systolic volume (LESV),left ventricular end-diastolic volume (LEDV) and left ventricular ejection fraction (LVEF) were detected before and after treatment.Moreover the levels of NT-pro-BNP,renin (R),endothelin (ET),norepinephrine (ET),hypersensitive C-reactive protein (hs-CRP),blood K+,blood Na+,heart rate (HR),Killip grading and incidence rates of adverse cardiovascular events were observed and compared between two groups.Results There were no significant differences in the levels of blood K + and blood Na + before and after treatment between two groups (P ＞ 0.05),however,the HR was decreased after treatment in both groups,as compared with that before treatment (P ＜ 0.05),moreover,the decrease degree in observation group was more obvious that that in control group (P ＜ 0.05).After treatment Killip grade was decreased in both groups,and the decrease degree in observation group was more obvious that that in control group (P ＜ 0.05).There were no significant differences in the levels of NT-proBNP,NE,R,ET and hs-CRP between two groups (P ＞ 0.05),however,which were significantly decreased after treatment in both groups,as compared with those before treatment (P ＜ 0.05),moreover,the levels of NT-proBNPNE,R,ET and hs-CRP in observation group were significantly lower than those in control group (P ＜ 0.05).Besides the incidence rate of adverse cardiovascular events in observation group was 17.1％,which was significantly lower than that in control group (P ＜ 0.05).Conclusion Recombinant human brain natriuretic peptide combined with Shenfu injection in treatment of acute myocardial infarction complicated by pump failure is effective,which can improve patient's cardiac function and neuroendocrine hormone levels and can decrease the incidence rate of adverse cardiovascular events.
Keywords：recombinant human brain natriuretic peptideShenfu injectionacute myocardial infarction with pump failure
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 19-22 )