Comparison of clinical features, pulmonary function, imaging indexes and life quality between patients with IPF complicated by pulmonary emphysema and patients with IPF without pulmonary emphysema
Abstract：Objective To investigate the differences in clinical characteristics,pulmonary function,imaging indexes and life quality between the patients with idiopathic pulmonary interstitial fibrosis (IPF) complicated by pulmonary emphysema and the patients with simple pulmonary interstitial fibrosis (SIPF).Methods The clinical data of 70 patients with IPF complicated by pulmonary emphysema (IPF + PE group) and 80 patients with SIPF (SIPF group) who were treated in our hospital from February 2014 to August 2015 were retrospectively analyzed.The differences in inflammatory factors,lung function,imaging parameters and life quality were observed and compared between the two groups.Results The levels of IL-8,IL-17,hs-CRP and TNF-α in IPF + PE group were significantly higher than those in SIPF group (P ＜ 0.01),however,the levels of FVC,FEV1,FEV1/FVC,MMEF and PEF in IPF + PE group were significantly lower than those in SIPF group (P ＜0.01).The levels of SpO2 in IPF + PE group were significantly lower than those in SIPF group (P ＜0.01),however,the levels of PETCO2 in IPF + PE group were significantly higher than those in SIPF group (P ＜ 0.01).Moreover except for limbs pain,the life quality scores in SIPF group were significantly higher than those in in IPF + PE group (P ＜ 0.01).Conclusion The pulmonary function and life quality of patients with IPF complicated by pulmonary emphysema are worse than those of patients with SIPF,with obvious imaging characteristics.
Keywords：pulmonary interstitial fibrosispulmonary emphysemapulmonary functioninflammatory factorsimaging characteristics
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 3716-3718 )