Effects of preoperative uterine arterial chemoembolization on tumor resection rate and survival quality of patients with cervical cancer
YANG Hui
Abstract：Objective To observe the effects of preoperative uterine arterial chemoembolization on tumor resection rate and quality of survival in patients with cervical cancer .Methods Ninety patients with cervical cancer were randomly divided into direct operation group and arterial intervention chemotherapy group ,with 45 patients in each group .The tumor size and adverse effects caused by chemotherapy in arterial intervention chemotherap were observed before and after chemotherapy , and surgical results were compared between two groups .Moreover the content of serum vascular endothelial growth factor (VEGF) and the expression levels of VEGF,aspartic proteinase 3 (Caspase-3), aspartic proteinase 9 (Caspase-9),tumor necrosis factor α-induced protein ( TNFAIP8 ) and peroxiredoxin 4 ( Prdx4 ) in cervical cancer tissues were detected after surgery.The life quality score on 1 year after operation,3-year relapse rate,lymph node metastasis rate and 3-year survival rate after operation were observed and compared between the two groups .Results After chemotherapy , the maximal diameter of tumor was 2.79 ±1.64cm in arterial intervention chemotherapy group with mild adverse reactions ,which was significantly smaller than that [(5.28 ±0.56)cm] before chemotherapy (P<0.05).As compared with that in direct operation group ,the radical resection rate in arterial intervention chemotherapy group was significantly increased (P<0.05),moreover, lymph node metastasis rate was significantly decreased (P <0.05).After surgery, the serum levels of VEGF-A,VEGF-C and VEGF-D were significantly decreased in arterial intervention chemotherapy group , furthermore , the expression levels of VEGF-A,VEGF-C, VEGF-D,TNFAIP8,Prdx4 in cervical cancer tissues were significantly decreased ,however, the expression levels of Caspase-3 and Caspase-9 were significantly increased,as compared with those in direct operation group (P<0.05). On 3 years after operation,the relapse rate,lymph node metastasis rate and survival rate in arterial intervention chemotherapy group were significantly lower than those in direct operation group ( P <0.05).In addition, there were no significant differences in life quality scores on 1 year after operation between two groups ( P>0.05 ) .Conclusion The preoperative uterine arterial chemoembolization can effectively decrease tumor size of patients with cervical cancer ,improve tumor radical resection rate and promote cancer cell apoptosis ,moreover ,which can reduce the serum indexes of metastasis and infiltration of tumor, and can improve long term efficacy without affecting the life quality of patients .
Keywords：cervical canceruterine arterial chemoembolizationtumor resection ratequality of survival
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 3530-3533,3538 )