Study on the therapeutic effects of beraprost combined with sildenafil on COPD complicated by pulmonary hypertension
Abstract：Objective To investigate the therapeutic effects of beraprost combined with sildenafil on chronic obstructive lung disease ( COPD) complicated by pulmonary hypertension .Methods Eighty patients with COPD complicated by pulmonary hypertension who were treated in our hospital from June 2014 to December 2015 were randomly divided into control group,beraprost group,sildenafil group,combination medication group (beraprost+sildenafil),with 20 patients in each group.The therapeutic effects on 1,3,6 months after treatment were observed and compared among the four groups .Results After treatment , the exercise tolerance of patients in beraprost group , sildenafil group , combination medication group was significantly improved,moreover,the blood gas analysis parameters,hemorheology indexes,myocardial enzyme indexes,plasma brain natriuretic peptide (BNP),left ventricular ejection fraction (LVEF),right atrial pressure,left ventricular size,PAP, 6-min walking distance and lung function were significantly improved in the three groups ( P <0.05 ) .Conclusion The beraprost combined with sildenafil can decrease disease attack frequency ,reduce death rate and improve life quality of patients with COPD complicated by pulmonary hypertension ,thus,which has better social and economic effects .
Keywords：beraprostsildenafilCOPDpulmonary hypertensionbrain natriuretic peptide
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 3392-3395 )