Effects of campto adjuvant chemotherapy on serum levels of IL-6,IL-10 and survival prognosis of patients with colon cancer

doi:10.3969/j.issn.1002-7386.2017.22.005

Abstract：Objective To investigate the effects of campto adjuvant chemotherapy on serum levels of interleukin -6 (IL-6), interleukin-10 (IL-10) and survival prognosis of patients with colon cancer .Methods A total of 116 patients with colon cancer who were admitted and treated in Department of Oncology of our hospital from January 2014 to January 2015 were randomly divided control group and observation group , with 58 patients in each group .The patients in control group were treated by postoperative FOLFOX6 chemotherapy combined with bevacizumab ,however,the patients in observation group , on the basis of control group , were given oral campto .The serum levels of IL-6, IL-10 were detected by enzyme-linked immunosorbent assay (ELISA) ,moreover, the clinical curative effects,serum parameters and survival prognosis were observed and compared between two groups .Results The overall remission rate and clinical benefit rate in observation group were significantly higher than those in control group (P<0.05).However there were no significant differences in incidence rates of drug adverse reactions between the two groups (P>0.05).Before treatment, there were no significant differences in the serum levels of IL-6,IL-10 between two groups (P>0.05),however, after treatment, the serum levels of IL-6,IL-10 in both groups were obviously lower than those before treatment (P<0.05), moreover,which in observation group were significantly lower than those in control group (P <0.05).After 2-year follow up,the lost follow-up rate was 0,and the survival rate in observation group was obviously higher than that in control group ,however , the relapse rate in observation group was obviously lower than that in control group (P<0.05).Before treatment, there were no significant differences in the life quality scores between two groups (P>0.05),however, after treatment, the life quality scores in both groups were significantly higher than those before treatment (P<0.05),moreover, the scores in observation group were obviously higher than those in control group (P<0.05).Conclusion The campto adjuvant chemotherapy can help to improve clinical curative effects obviously on colon cancer,which can lower the serum levels IL-6,IL-10 to improve survival prognosis of patients , thus,which is worthy using widely in clinical practice .