Effects of Shensongyangxin capsule combined with western medicines on neuroendocrine system and endothelial function of patients with chronic heart failure

ZHANG Dacheng; ZHANG Chunyu

doi:10.3969/j.issn.1002-7386.2017.22.001

Abstract：Objective To investigate the effects of Shensongyangxin capsule combined with western medicines on neuroendocrine system and endothelial function of patients with chronic heart failure (CHF).Methods Sixty patients with CHF were randomly divided into control group and observation group ,with 30 patients in each group .The patients in control group were treated by conventional western medicines including diuretics , ACEI and beta blockers , however , the patients in observation group,on the basis of control group ,were treated by Shensongyangxin capsule ,with a treatment course of 12 weeks for both grousp .Then the therapeutic effects were observed and compared between two groups .Moreover the changes of echocardiographic left ventricular end diastolic diameter ( LVEDd ) , left ventricular end systolic diameter ( LAESd ) , left ventricular ejection fraction ( LVEF ) , cardiac output ( CO ) , fractional shortening ( FS ) and vascular endothelial function;vascular endothelial function , neuroendocrine factors in plasma endothelin ( ET ) , calcitonin gene related peptide ( CGRP ) , serum nitric oxide (NO),plasma B type natriuretic peptide (BNP),angiotensin Ⅱ (Ang Ⅱ),aldosterone (ALD),plasma renin activity ( PRA) before and after treatment were observed and compared between two groups .Results The total effective rate in observation group was superior to that in control group ( P<00.5 ) .After treatment the cardiac ultrasound indexes were significantly improved in both groups , as compared with those before treatment ( P <0.05).The LVEDd and LAESd in observation group were obviously lower than those in control group ,however, the LVEF,FS,CO in observation group were significantly higher than those in control group (P<0.05).After treatment the FMD,NED, NO and CGRP were increased in both groups,but the levels of ET,Ang II,ALD,PRA,BNP were significantly decreased,as compared with those before treatment (P<0.05),moreover there were significant differences between two groups (P<0.05).After treatment the cardiac function grade was obviously improved in both groups , moreover the improvement degree in observation group was superior to that in control group ( P<0.05) .Conclusion Shensongyangxin capsule combined with western medicines has definite therapeutic effects on CHF,moreover,which can improve the neuroendocrine system and endothelial function of patients .