Therapeutic effects of sitagliptin combined with irbesartan on early diabetic nephropathy
Abstract：Objective To observe the therapeutic effects of sitagliptin combined with irbesartan on early diabetic nephropathy.Methods Ninety patients with early diabetic nephropathy who were treated in our hospital from November 2015 to November 2016 were divided into control group and observation group according to random number table.The patients in control group were treated by sitagliptin only,however,the patients in observation group were treated by sitagliptin combined with irbesartan,then the therapeutic effects,the changes of serum inhibin C (CysC),HbA1c, microalbuminuria (24h) and UAER urinary albumin excretion rate (U-mAlb) before and after treatment and adverse effects were observed and compared between two groups.Results Before treatment there were no significant differences in the levels of CysC,HbA1c,U-mAlb, UAER between two groups (P >0.05),however after 1-month treatment,the decrease degree of CysC,HbA1c,U-mAlb, UAER in observation group was significantly higher than that in control group (P <0.05), after 3-month treatment,the decrease degree of CysC,HbA1c,U-mAlb,UAER was significantly higher than that in control group (P <0.01).However there were no significant differences in the incidence rates of adverse reactions between two groups(P>0.05).Conclusion The irbesartan combined with sitagliptin can not only effectively improve renal function of patients with early diabetic nephropathy,but also can effective protect kidney of patients,thus,which is worth using widely in clinical practice.
Keywords：early diabetic nephropathyirbesartansitagliptin
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 3233-3235 )