Study on the correlation between serum levels of uric acid and cerebral microbleeds in patients with acute ischemic stroke
LIU Jianjun
WANG Jianmin
ZHONG Guangjuan
Abstract：Objective To investigate the correlation between serum levels of uric acid and cerebral microbleeds (CMBs) in patients with acute ischemic stroke.Methods The demographic characteristics,clinical data including laboratory and image parameters about 212 patients with acute ischemic stroke who were admitted and treated in our hospital from Mar 2008 to May 2015 were retrospectively analyzed.The diagnosis of CMBs was performed by using T2?-weighted gradient-echo MRI.Using Logistic regression analysis to evaluate the independent correlation between uric acid and CMBs.Results Among 212 patients with acute ischemic stroke,94 patients had CMBs (44.3%).As compared with the patients without CMBs,the average age in patients with CMBs was older,and uric acid levels were higher, the probability with hypertension,anamnestic cerebral stroke history,WMLs grade and high total cholesterol was higher in patients with CMBs (P<0.05). As compared with those of patients in uric acid level 1 quantile group,the risks of patients with hypertension, hypercholesterolemia,heart diseases,CMBs were higher,moreover,the risks with higher blood pressure and bigger body mass index in uric acid level 1 quantile group were higher (P<0.05).The single factor analysis showed that high blood pressure, hypercholesterolemia, stroke history,SBP,DBP,WMLs grading and uric acid were closely correlated with the occurrence of CMBs (P<0.05). Moreover multivariate analysis showed that uric acid,WMLs classification,stroke history,hypercholesterolemia and high blood pressure were independent prediction factors of occurrence of CMBs,and the OR value of uric acid levels was significantly higher than that of the other indexes (P <0.05). Conclusion The serum levels of uric acid are independent correlation factors of CMBs in patients with acute ischemic stroke.
Keywords：uric acidcerebral microbleedscorrelationacute cerebral ischemic stroke
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 3213-3216 )