Effects of risperidone on the levels of blood glucose,blood lipid and thyroid hormone in patients with schizophrenia

WU Huiqing; YANG Mei; SHENG Li

doi:10.3969/j.issn.1002-7386.2017.20.006

Abstract：Objective To investigate the effects of risperidone on the levels of blood glucose,blood lipid and thyroid hormone in patients with schizophrenia. Methods A total of 116 patients with schizophrenic who were treated in our hospital from January 2014 to December 2015 were enrolled in the study, according to random number table, these patients were randomly divided into risperidone group and aripiprazole group, with 58 patients in each group. The patients in both groups were treated by antipsychotic drugs for the first time. The levels of blood glucose, blood lipids and thyroid hormones were detected and compared between two groups before and after treatment. Results After treatment,the levels of IRI,FPG,LDL-C and TC in risperidone group were significantly higher than those in aripiprazole group (P<0. 05). The levels of FPG,FINS, IRI and TSH in both groups were significantly increased,however, the levels of T3,FT3,FT4 in both groups were significantly decreased,as compared with those before treatment (P<0. 05). After treatment,the average PANSS scores in risperidone group were 57. 6 ± 11. 3 points,which were significantly lower than those (81. 5 ± 12. 6 points) before treatment (P<0. 05). Moreover the average PANSS scores in aripiprazole group were (58. 4 ± 12) points,which were significantly lower than those (82. 2 ± 11. 9 points) before treatment (P<0. 05),however, there were no significant differences in average PANSS scores between two groups after treatment (P >0. 05). Conclusion The therapeutic effects of risperidone on schizophrenia are similar to those of aripiprazole,but it should be paid much attention to monitoring the changes of blood lipid,blood glucose and thyroid gland function of patients.