Therapeutic effects of bi level positive airway pressure ventilation combined with fasudil hydrochloride injection on CPHD complicated by type Ⅱ respiratory failure
DENG Heqian
HU Kairui
Abstract：Objective To observe the therapeutic effects of Bi level positive airway pressure ventilation combined with fasudil hydrochloride injection on chronic pulmonary heart disease ( CPHD) complicated by type II respiratory failure in order to provide reference for the more effective treatment of CPHD complicated by type II respiratory failure in the future. Methods A total of 120 patients with CPHD complicated by type II respiratory failure who were treated in our hospital from January 2015 to June 2016 were randomly divided into control group and observation group. The patients in control group were treated by routine supportive therapy+bi level positive airway pressure ventilation,however,the patients in observation group, on the basis of control group, were treated by fasudil hydrochloride injection. The heart rate,respiration,mMRC score,blood gas indexes,pulmonary ventilation function, levels of CRP and NT-proBNP as well as pulmonary artery pressure changes were observed and compared between two groups. Results The improvement status of breathing, heart rate and mMRC score in observation group was more obvious than that in control group (P <0. 05). The levels of pH,PaO2,SaO2 and PaCO2 in observation group were significantly higher than those in control group (P<0. 05),moreover,the levels of FEV1％ and FEV1/FVC were significantly higher than those in control group (P <0. 05). However the levels of CRP and NT-proBNP in observation group were significantly lower than those in control group (P<0. 05). The improvement status of PASP,PADP, MPAM in observation group was superior to that in control group (P<0. 05). Conclusion The fasudil hydrochloride injection combined with bi level positive airway pressure ventilation can significantly improve pulmonary ventilation function of patients with CPHD complicated by type II respiratory failure, and can correct respiratory failure, meanwhile, which can alleviate inflammatory reaction and reduce pulmonary artery pressure,thus, which has broad application prospects.
Keywords：chronic pulmonary heart diseasetype 2 respiratory failureBi level positive pressure ventilationfasudil hydrochloride injection
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 3059-3063 )