The individual differences of pepsinogen content and its value in differential diagnosis between chronic atrophic gastritis and early gastric cancer

WANG Su; JIANG Junyan; ZHENG Zidan

doi:10.3969/j.issn.1002-7386.2017.19.012

Abstract：Objective To investigate the differences of the contents of pepsinogen Ⅰ(PGⅠ),PGⅡ and PGⅠ/PGⅡ in patients with atrophic gastritis and patients with early gastric cancer patients in order to provide a theoretical basis for the differential diagnosis of disease and disease classification.Methods Fifty-seven patients with mild gastritis were enrolled as control group, 29 patients with chronic atrophic gastritis were enrolled as atrophic gastritis group and 7 patients with gastric cancer were enrolled as gastric cancer group,who were treated in our hospital from January 2016 to August 2016.The serum levels of PGⅠ,PGⅡ and PGⅠ/PGⅡ ratio were detected and compared among the three groups.Results The patient's sex and educational history had no effects on the prevalence of atrophic gastritis and gastric cancer (P>0.05),however, the monthly income in different age groups had effects on the prevalence (P<0.05).The levels of PGⅠ/PGⅡin atrophic gastritis group were significantly lower than those in contol group,however,the levels of PGⅡwere obviously higher than those in control group (P<0.05).The levels of PGⅠ,PGⅠ/PGⅡin gastric cancer group were significantly lower than those in contol group and those in atrophic gastritis group, but the levels of PGⅡwere significantly higher than those in contol group and those in atrophic gastritis group (P<0.05).The levels of PGⅠ,PGⅠ/PGⅡin moderate and severe atrophic gastritis groups were significantly lower than those in mild atrophic gastritis group,however,the levels of PGⅡwere significantly higher than those in mild atrophic gastritis group (P<0.05).The levels of PGⅠ,PGⅠ/PGⅡin severe atrophic gastritis groups were significantly lower than those in moderate atrophic gastritis group,but the levels of PGⅡwere significantly higher than those in moderate atrophic gastritis group (P<0.05).There were no significant differences in the levels of PGⅡin different developmental stages of gastric cancer (P>0.05).The levels of PGⅠ,PGⅠ/PGⅡ in aggressive-phase and advanced gastric cancer were significantly lower than those in early gastric cancer,moreover, the levels of PGⅠ,PGⅠ/PGⅡin advanced gastric cancer were significantly lower than those in aggressive-phase gastric cancer (P<0.05).Conclusion The detection of pepsinogen has a certain value in differential diagnosis between chronic atrophic gastritis and early gastric cancer,which has the advantages of simplicity and high-performance, therefor,which is worth using widely in clinical practice.