Study on the relationship between bilirubin levels and intracranial atherosclerotic stenosis in patients with cerebral infarction

doi:10.3969/j.issn.1002-7386.2017.19.006

Abstract：Objective To investigate the correlation between serum bilirubin levels and intracranial atherosclerotic stenosis in patients with cerebral infarction.Methods A total of 100 patients with cerebral infarction who were admitted and treated in our hospital from January 2015 to December 2016 were divided into control group and experimental group.The 50 patients with mild stenosis or without stenosis were were enrolled as control group,and the other 50 patients with moderate,severe stenosis or occlusion were enrolled as experimental group,moreover, according to the degree of intracranial artery stenosis, the 50 patients in experimental group were redivided into two subgroups.The serum levels of bilirubin were detected and compared among different groups.The related risk factors with intracranial arterial stenosis were analyzed by means of Logistic regression analysis.Results The serum levels of TBIL ,IBIL and DBIL in experimental group were significantly lower than those in control group (P<0.01 or P<0.05).The serum levels of TBIL, IBIL and DBIL in patients with severe stenosis or occlusion were significantly lower than those in patients with moderate stenosis (P<0.05).Logistic regression analysis showed that hypertension (r=0.833,P=0.789), diabetes mellitus (r=0.076,P=0.032) were positively correlated to intracranial artery stenosis,however, the TBIL levels were negatively related with intracranial artery stenosis (r=-0.076,P=0.032).Conclusion There is a negative correlation between serum bilirubin and intracranial atherosclerotic stenosis,that is,the lower the serum bilirubin levels,the higher the risk of intracranial artery stenosis.