Application value of combined detection of serum levels of CYFRA21-1 with SCC-Ag in diagnosis of esophageal cancer
HE Xudong
Abstract：Objective To analyze the application value of combined detection of serum levels of cell keratin 19 fragment antigen (CYRRA21-1) with squamous cell carcinoma associated antigen (SCC-Ag) in diagnosis of esophageal cancer.Methods A total of 874 patients with esophageal cancer who were treated in our hospital from July 2014 to July 2016 were enrolled as trial group,at the same time, 874 healthy subjects were enrolled as control group.The serum levels of cytokeratin 19 fragment antigen (CYRRA21-1) and squamous cell carcinoma antigen (SCC-Ag) were detected and compared between two groups.Results The levels of CYRRA21-1 in trial group were higher than those in control group (38.19± 49.75 vs 4.86±2.79),and the levels of SCC-Ag in trial group were higher than those in control group (28.77±52.26 vs 2.05±1.83),there were significant differences between two groups (P<0.01).However there were no significant differences in CYRRA21-1和SCC-Ag among different differentiation degrees of tumor (P>0.05).The positive rate of CYRRA21-1 in trial group was 79.75％,and the positive rate of SCC-Ag in trial group was 74.83％.ROC curve analysis showed that the combined detection of CYRRA21-1 with SCC-Ag had a certain guidance significance in diagnosis of esophageal cancer,which could increase positive rate of diagnosis,with specificity being 100％.Conclusion The cell differentiation degree is not necessarily correlated to serum levels of CYRRA21-1 and SCC-Ag,but combined detection of serum levels of CYRRA21-1 with SCC-Ag is helpful to improve diagnosis rate of esophageal cancer and has certain application value.
Keywords：cell keratin 19 fragment antigensquamous cell carcinoma associated antigenesophageal cancer
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2890-2892,2897 )