Expression and clinical significance of Rb protein,β and γ-catenin in metastatic lymph nodes from advanced gastric carcinoma
Abstract：Objective To investigate the expression of Rb and re-expression of β and γ-catenin in cancerous cells of metastatic lymph nodes from advanced gastric carcinoma.Methods The expression levels of Rb and β and γ-catenin were detected by immunohistochemistry in 86 cases of primary focus of advanced gastric carcinoma as well as corresponding metastasis lymph nodes.Results Among 86 cases of primary focus of advanced gastric carcinoma,the expression of Rb was detected in 56 case (65.12％),and re-expression of β-and γ-catenin in metastatic cancerous cells was detected in 33 case (38.37％).The expression of Rb was closely related with tumor differentiation degree (P<0.05),and the re-expression of β-and γ-catenin was closely correlated to tumor differentiation degree (P<0.05).The re-expression ofγ-catenin in metastatic cancerous cells was closely correlated to tumor pathological types (P<0.05),however, the re-expression of βcatenin in metastatic lymph nodes was not related with tumor pathological types (P>0.05).Moreover the expression of Rb in metastatic lymph nodes was related with that of β-catenin,however,which was not correlated to tumor pathological types,tumor size,infiltration degree (P>0.05).There were significant differences in 3-year survival rates between patients with positive re-expression of β or γ-catenin and patients with negative re-expression ofβ or γ-catenin.Conclusion The expression of Rb protein is closely related with the progress of advanced gastric carcinoma and with the re-expression of β-catenin in cancerous cells of metastatic lymph nodes.The re-expression of β-and γ-catenin in cancerous cells of metastatic lymph nodes from advanced gastric carcinoma plays an important role in the pathogenesis of advanced gastric carcinoma and both factors have synergistic reaction and play important role in aggregation and growth of cancer cells in metastatic focus.
Keywords：Rbβ and γ-cateninadvanced gastric carcinomametastatic lymph nodesimmunohistochemistrysurvival duration
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 2885-2889 )