Study on the clinical diagnostic value of serum levels of sFlt-1 and D-dimer in patients with preeclampsia

LU Guangjuan; WU Longyu; CHEN Junhong

doi:10.3969/j.issn.1002-7386.2017.18.009

Abstract：Objective To investigate the clinical diagnostic value of serum levels of soluble fms-like tyrosine kinas (sFlt-1)and D-dimer (DD)in patients with preeclampsia (PE). Methods A total of 100 patients with PE who were admitted and treated in our hospital from October 2013 to May 2016 were enrolled in the study. These patients were divided into mild PE group (n = 56)and severe PE group (n = 46),at the same time,the other 34 healthy pregnant women were enrolled as control group. The general informations and laboratory parameters were recorded,and serum levels of sFlt-1 and DD were detected. ROC curve was used to evaluate the diagnostic value of sFlt-1 and DD in PE. Results There were significant differences in the serum levels of sFlt-1 and DD among the three groups with each other. The sFlt-1 levels in mild PE group were closely correlated to those of DD (r = 0. 338,P < 0. 05),and sFlt-1 levels in severe PE group were also closely associated with those of DD (r = 0. 436,P < 0. 01). The AUC of sFlt-1,DD and sFlt-1 combined with DD in differential diagnosis between patients with PE and healthy pregnant women were 0. 749,0. 722,0. 795,respectively. The AUC of sFlt-1,DD and sFlt-1 combined with DD in differential diagnosis between mild PE and severe PE were 0. 632,0. 706,0. 711,respectively. Conclusion The serum levels of sFlt-1 and DD can be regarded as reference indexes of clinical diagnosis of PE.