Effects of preemptive analgesia combined with multimodal analgesia on immune function and cytokines of patients with femoral neck fracture
LI Xiangfu
Abstract：Objective To analyze the effects of preemptive analgesia combined with multimodality analgesia on immune function and cytokines of patients with femoral neck fracture. Methods Ninety patients with femoral neck fracture who received internal fixation with hollow nail in our hospital from January 2011 to September 2015 were divided into group A, group B and group C according to random number table,with 30 patients in each group. The patients in group A were treated by preemptive analgesia,and the patients in group B were treated by multimodality analgesia,however,the patients in group C were treated by preemptive analgesia combined with multimodality analgesia. The analgesic effects (VAS),sleeping scoring, analgesic agent dosage,immunity function indexes including CD +4 ,CD +8 ,CD +4 / CD +8 ,cytokines including interleukin-6 (IL-6),IL-1β,tumor necrosis factor-α (TNF-α) were observed and compared among the three groups. Results As compared with those in group A,the sleeping scores on 12h,24h after operation in group B and in group C on 12h,24h,48h after operation were significantly decreased (P < 0. 05). As compared with those in group B,the sleeping scores on 12h,24h, 48h after operation in group C were significantly decreased (P < 0. 05). Moreover the sleeping scores on 12h,24h after operation in group B and in group C were significantly lower than those in group A. As compared with those in group A,the analgesia number of times,analgesia dosage,VAS scores on 12h,24h,48h after operation,morphine dosage,the levels of IL-6, IL-1β and TNF-α on 12,24,48h after operation in group B and C were significantly decreased (P < 0. 05). As compared with those in group B,the analgesia number of times,analgesia dosage,VAS scores on 12,24,48h after operation,morphine dosage,the levels of IL-6,IL-1β and TNF-α on 12,24,48h after operation in group C were significantly decreased (P <0. 05). As compared with those in group A,the levels of CD +8 and CD +4 / CD +8 on 12,24,48h after operation in group B and group C were significantly decreased (P < 0. 05). As compared with those in group B,the levels of CD +4 ,CD +8 and CD +4 /CD +8 in group C were significantly decreased on 12,24,48h after operation (P < 0. 05). Conclusion The preemptive analgesia combined with multimodality analgesia has more effective analgesia effects in patients with femoral neck fracture who receive internal fixation with hollow nail,which can decrease the dosage of narcotic analgesics and improve the immune function of patients.
Keywords：preemptive analgesiamulti-modal analgesiafemoral neck fractureimmune functioncytokines
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 2752-2755,2760 )