Study on the correlation between microvessel density and tumor marker levels in different TNM stages of liver cancer

doi:10.3969/j.issn.1002-7386.2017.18.001

Abstract：Objective To investigate the correlation between microvessel density(MVD)and tumor marker levels in different TNM stages of liver cancer. Methods Seventy patients with liver cancer who received surgical treatment were enrolled as liver cancer group,the other 20 patients with liver external injury who underwent surgery were enrolled as liver surgery group, moreover 20 healthy subjects were enrolled as control group,The MDA levels were detected by immunohistochemistry in tumor tissues,paracancerous tissues and normal liver tissues,and the serum levels of alpha fetoprotein (AFP),tumor specific growth factor (TSGF)and vascular endothelial growth factor (VEGF)were detected by enzyme linked immunosorbent assay (ELISA). Results As compared with those in normal liver tissues,the levels of MVD in tumor tissues and adjacent tissues were higher,moreover,which in tumor tissues were significantly higher than those in adjacent tissues (P < 0. 05). The levels of MVD in tumor tissues were increased with the increase of TNM stages,furthermore,there were significant differences in the levels of MVD among different stages,stageⅠ < stageⅡ < stageⅢ < stageⅣ (P < 0. 05). As compared with those in control group,the serum levels of AFP,TSGF and VEGF were significantly increased in liver cancer group (P < 0. 05). The serum levels of AFP,TSGF,VEGF were increased with the increase of TNM stages,moreover,there were significant differences among different stages,stageⅠ < stageⅡ < stageⅢ < stageⅣ (P < 0. 05). Besides the serum levels of AFP,TSGF and VEGF were positively correlated with those of MVD in liver cancer group (r = 0. 853,0. 920,0. 846, respectively,P < 0. 05). Conclusion The levels of MVD and tumor markers-AFP,TSGF,VEGF in tumor tissues of patients with liver cancer are correlated to clinical TNM stage,the higher the TNM stage,the higher the levels of MVD,AFP,TSGF, VEGF,moreover,the serum levels of AFP,TSGF,VEGF are positively correlated with those of MVD,it is suggested that the levels of AFP,TSGF,VEGF are related with the invasion and metastasis of liver cancer.