Therapeutic effects of metoprolol combined with irbesartan on hypertensive heart disease

JIANG Hongliang

doi:10.3969/j.issn.1002-7386.2017.17.009

Abstract：Objective To investigate the therapeutic effects of metoprolol combined with irbesartan on hypertensive heart disease.Methods A total of 132 patients with hypertensive heart disease who were treated in our hospital from October 2015 to May 2016 were randomly divided into two groups,trial group (n=67) and control group (n=65).The patients in control group were treated by oral irbesartan ,however,the patients in trial group,on the basis of control group were treated by metoprolol.After 3-month treatment, the blood pressure,heart function classification,related blood indexes including blood glucose, triglyceride,creatinine,cholesterol and alanine aminotransferase were observed and compared between two groups.Besides,the therapeutic effects were evaluated and compared between two groups.Results Before treatment,there were no significant differences in systolic pressure and diastolic pressure between two groups (P>0.05).However after 3-month treatment,the levels of blood pressure were obviously decresased in both groups (P<0.05), moreover the decrease degree of systolic pressure and diastolic pressure in trial group was more obvious than that in control group (P<0.05).According to the heart function classification criteria (NYHA),there was no significant difference in heart function classification between two groups before treatment (P>0.05),however,after treatment, there was a significant difference in heart function classification between two groups (P>0.05).There were no significant differences in blood glucose, triglyceride, creatinine, cholesterol and alanine aminotransferase between two groups (P>0.05).Furthermore the total effective rate in trial group was significantly higher than that in control group (P<0.05).Conclusion The combination application of metoprolol with irbesartan in treatment of hypertensive heart disease can effectively reduce blood pressure,improve heart function,with good safety, thus,which is worth using widely in clinical practice.