The plasma levels of FGF-21 in patients with acute myocardial infarction by preliminary diagnosis and its clinical significance

doi:10.3969/j.issn.1002-7386.2017.17.002

Abstract：Objective To observe the changes of plasma levels of fibroblast growth factor 21(FGF-21) in newly diagnosed acute myocardial infarction (AMI) patients, and to explore the correlation between its levels and plasma glucose,blood lipoids as well as AMI events.Methods The plasma levels of FGF-21 were detected by ELlSA in 55 cases of AMI (AMI group) and 52 healthy subjects (control group),and the correlation between the plasma levels of FGF-21 in newly diagnosed AMI patients and BMI,FBG,HbA1c,BUN,SCr,SUA,TG,Hs-CRP,AST,HDL-C,LDL-C,AMI events was evaluated by multivariate logistic regression analysis.Results The levels of BMI,TG,BUN,SCr,SUA,Hs-CRP,AST,FBG,HbA1c,FGF-21in AMI with type 2 diabetes group were significantly higher than those in control group,however, the levels of TC,HDL-C,LDL-C were significantly lower than those in control group (P<0.05).Moreover the levels of BUN,SCr,SUA, AST,FBG,HbA1c,FGF-21 in AMI without diabetes group were significantly higher than those in control group,however, the levels of TC,HDL-C,LDL-C were significantly lower than those in control group (P<0.05).The patient's age,the levels of BUN,SCr,FBG,HbA1c, BNP,CKMB in AMI with type 2 diabetes group were significantly higher than those in AMI without diabetes group (P<0.05).The levels of FGF-21 in first diagnosed AMI patients were positively correlated with those of TG (r=0.627,P<0.01).In healthy subjects,the plasma levels of FGF-21 were positively correlated with those of TG (r=0.318,P<0.01).The multivariant Logistic regression showed that patient's age, HbA1C,FGF-21 were independent risk factors of AMI.Conclusion The plasma levels of FGF-21 are compensationally increased when myocardial ischemia results in myocardial damage,which may play an important role during myocardial preservation.