Therapeutic effects of bronchial arterial perfusion chemotherapy combined with embolization on advanced central type non-small cell lung cancer

ZHAO Yangguang

doi:10.3969/j.issn.1002-7386.2017.16.007

Abstract：Objective To observe the therapeutic effects of bronchial arterial perfusion chemotherapy combined with embolization on advanced central type non-small cell lung cancer.Methods Ninety patients with advanced central type non-small cell lung cancer were randomly divided into control group and trial group,with 45 patients in each group.The patients in control group were treated by systemic intravenous chemotherapy,however,the other 45 patients in trial group were treated by bronchial arterial perfusion chemotherapy combined with embolization.The short-term curative effect,long-term curative effects,adverse effects,complications,satisfaction degree and the changes of levels of CEA,CA125,CA19-9,NSE,TNF-α,CRP,IL-6,CD+3,CD+4,CD+8,CD+4/CD+8 before and after treatment were observed and compared between two groups.Results The short-term curative effect,long-term curative effects and satisfaction degree in trial group were much better than those in control group,moreover, the adverse effects and complications in trial group were significantly less than those in control group (P<0.05).After treatment the levels of CEA,CA125,CA19-9,NSE,TNF-α,CRP,IL-6 and CD+8 were significantly decreased,as compared with those before treatment,however,the levels of CD+3,CD+4 and CD+4/CD+8 were obviously increased in both groups,as compared with those before treatment (P<0.05),moreover, these indexes mentioned above in trial group were superior to those in control group (P<0.05).Conclusion The bronchial arterial perfusion chemotherapy combined with embolization in treatment of advanced central type non-small cell lung cancer can obviously increase survival rate of patients,improve effectively cellmediated immunity imbalance state, decrease the levels of inflammatory cytokines,without obvious adverse effects.