Effects of epidural labor analgesia on the balance of T cell subsets and cytokines of parturients

LI Jing; XIU Yufang; ZHOU Jing

doi:10.3969/j.issn.1002-7386.2017.15.010

Abstract：Objective To investigate the effect of epidural labor analgesia on the balance of T cell subsets and cytokines of parturients.Methods Fifty-six term birth parturients who were admitted in our hospital from October 2014 to December 2015 were divided into two groups according to random number table:control group (n=28) and observation group (n=28).The parturients in control group underwent spontaneous delivery, however, the parturients in observation group received epidural labor analgesia.The visual analogue score (VAS) was performed in T1 (latent period),T2 (at full dilatation),T3 (fetal disengagement),and the active duration in the first stage of labor was recorded,moreover, the duration of second stage of labor and third stage of labor as well as neonatal Apgar score were recorded.Besides the levels of cortisol, IL-1β,IL-10 and T cell subsets of parturients were detected in T1,T2,T3.Results The active duration in the first stage of labor in observation group was significantly shorter than that in control group (P<0.05),however,tere were no significant differences in the duration of second stage of labor and third stage of labor as well as neonatal Apgar score between two groups (P>0.05).The levels of cortisol in T2 in observation group were significantly lower than those in control group (P<0.05),moreover, the levels of CD+3,CD+4 and CD+4/CD+8 were decreased at different extent in both groups, besides, the decrease degree of T cell subsets in T3 in observation group was significantly lower than that in control group (P<0.05).Conclusion The epidural labor analgesia can relieve pain and the other stress responses to improve maternal immune function suppression,which can maintain balance of Th1/Th2.