Correlation between dopamine D2 receptor gene polymorphism and postoperative delirium in patients undergoing coronary artery bypass grafting
Abstract：Objective To investigate the correlation between dopamine D2 receptor (DRD2) gene polymorphism and postoperative delirium in patients undergoing coronary artery bypass grafting (CABG), and to analyze the risk factors of postoperative delirium.Methods A total 150 patients who underwent coronary artery bypass grafting were enrolled in the study.The incidence rate and risk factors of postoperative delirium were analyzed by taking 《Delirium rating scale 98 revised edition》as diagnosis criteria for delirium,moreover, DRD2 genotypes were detected by gene sequencing.The correlation between rs6275,rs6277 polymorphism and delirium was analyzed.Results The incidence rate of postoperative delirium was 8.0% (12/150).The interclass univariate Logistic regression analysis results showed there were significant differences in cerebral infarction (OR=0.784,95%CI 0.631～0.975,P<0.05),surgery duration (OR=2.251,95%CI 0.941～5.380,P<0.05), extracorporeal circulation time (OR=1.057,95%CI 0.703～1.590,P<0.05)and intensive care unit duration (OR=1.890,95%CI 1.201～2.973,P<0.01).However there were no significant differences in frequencies of genotype and alleles of rs6275 polymorphism between case group and control group (OR=1.265,95%CI 0.697～2.303,P>0.05),but there were significant differences in frequencies of genotype and alleles of rs6277 polymorphism between the two groups (OR=2.276, 95%CI 1.142～4.523,P<0.05).The Logistic multifactor stepwise regression analysis showed that cerebral infarction, ICU duration and CC genotype of rs6277 were risk factors of postoperative delirium (P<0.01 or P<0.05).Conclusion To perform DRD2 gene screening in cerebral infarction patients with high risk factors may be helpful for prevention of occurrence of postoperative delirium.
Keywords：coronary artery bypass graftingpostoperative deliriumincidence raterisk factors
Publication Date：2017-01-01